Groundbreaking Research To Be Conducted in the Weimaraner - Patent Ductus Arteriosus
Researchers at the University of Missouri would like to identify genetic
variants associated with PDA in the Weimaraner.
• You do NOT have to travel to MU to participate in this study
• PLEASE participate if you have:
– Weimaraner that has been diagnosed with PDA
– Sire / *Dam of a Weimaraner that has been diagnosed with PDA
– Littermate of a Weimaraner that has been diagnosed with PDA
• Please contact MUcvmCardiology@missouri.edu for more information
Patent Ductus Arteriosus
CAUSE
Patent ductus arteriosus (also called PDA) is a birth defect in the heart. It is caused by incomplete changes in the heart's circulation when a dog is born.
The ductus arteriosus is an important blood vessel that ensures that blood does not go to the lungs unnecessarily as the fetus is developing in the uterus.
During the first few hours after birth, this blood vessel naturally closes off. This allows blood to travel normally through the lungs for oxygenation as the lungs begin to function when the puppy takes its first breath. In some puppies, the ductus arteriosus remains open (patent). This results in serious, life-threatening changes in the way that the heart pumps blood through the heart and to the rest of the body.
CLINICAL SIGNS
As the disease process progresses heart failure can ensue which include
signs of shortness of breath, coughing, weakness, and exercise
intolerance.
DIAGNOSIS
Most cases of patent ductus arteriosus are found in perfectly healthylooking puppies when a heart murmur is detected on routine examination.
A heart murmur is the sound produced by blood moving through the heart
in a turbulent fashion.
PDA murmurs produce a very distinctive sound. If there is a concern that
the murmur may indicate a patent ductus arteriosus, then further evaluation is warranted.
Usually, radiographs (x-rays) are taken of the chest to evaluate the size
and shape of the heart and to evaluate the lungs. An electrocardiogram
(ECG) depicts the pattern of electrical activity in the heart and any
irregularities in the heart's rhythm (arrhythmias). The ECG may show
changes that support a diagnosis of a PDA. An echocardiogram, (cardiac
ultrasound), is the test of choice for a PDA. An image of the inside of the heart is displayed in real time and allows the cardiologist to observe the abnormal communication between the aorta and pulmonary artery.
PROGNOSIS
Having a patent ductus arteriosus is not usually compatible with a normal
life span unless the PDA is corrected (closed).
TREATMENT/PROCEDURE
The goal of treatment is to close the ductus arteriosus. This can be
accomplished through thoracotomy (an open-chest surgery) or through
cardiac catheter-based (minimally-invasive surgery) occlusion.
It is important that one of these two procedures is performed as soon as
possible after the diagnosis is made. In some cases, waiting too long
allows other very serious complications to develop and creates the need for even more extensive treatment.